Product Data Sheet
Taurohyodeoxycholic acid
Catalog No. A26263
Taurohyodeoxycholic acid, an endogenous metabolite and 6 alpha-hydroxylated bile acid, exhibits anti-inflammatory properties by significantly reducing colonic myeloperoxidase (MPO) activity, TNF-α, IL-6 serum levels, and COX-2 expression. It has been shown to alleviate ulcerative colitis induced by trinitrobenzene sulfonic acid by modulating the balance between Th1/Th2 and Th17/Treg cells. Additionally, taurohyodeoxycholic acid improves outcomes in high-fat diet-induced nonalcoholic fatty liver disease in murine models and protects against hepatotoxicity in bile fistula rats. This compound is valuable for research into nonalcoholic fatty liver disease (NAFLD), colitis, and biliary fistula conditions.
Chemical Information
| Catalog Num | A26263 |
|---|---|
| M. Wt | 499.70 |
| Formula | C26H45NO6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2958-04-5 |
| Synonyms | |
| SMILES | C[C@@]12[C@]3([H])[C@](C[C@@H]([C@]1([H])C[C@@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)C |
Biological Activity
| Description | Taurohyodeoxycholic acid, an endogenous metabolite and 6 alpha-hydroxylated bile acid, exhibits anti-inflammatory properties by significantly reducing colonic myeloperoxidase (MPO) activity, TNF-α, IL-6 serum levels, and COX-2 expression. It has been shown to alleviate ulcerative colitis induced by trinitrobenzene sulfonic acid by modulating the balance between Th1/Th2 and Th17/Treg cells. Additionally, taurohyodeoxycholic acid improves outcomes in high-fat diet-induced nonalcoholic fatty liver disease in murine models and protects against hepatotoxicity in bile fistula rats. This compound is valuable for research into nonalcoholic fatty liver disease (NAFLD), colitis, and biliary fistula conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
