Product Data Sheet
GW-405833
Catalog No. A26303
GW-405833 is a selective agonist of the cannabinoid receptor 2 (CB2), with an EC50 value of 0.65 nM. It exhibits a strong affinity for CB2, while displaying significantly lower activity at CB1, with EC50 and Ki values of 16.1 μM and 4772 nM, respectively. In addition to its agonistic effects at CB2, GW-405833 acts as a non-competitive antagonist at CB1, mediating analgesic and anti-inflammatory effects. Furthermore, it inhibits forskolin-stimulated cAMP production and down-regulates HIF-1α, potentially alleviating acute liver failure through modulation of glycolysis. This compound is useful for research in pain management, inflammation, and liver pathology.
Chemical Information
| Catalog Num | A26303 |
|---|---|
| M. Wt | 447.35 |
| Formula | C23H24Cl2N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 180002-83-9 |
| Synonyms | L768242 |
| SMILES | O=C(C1=C(C(Cl)=CC=C1)Cl)N2C3=C(C=C(OC)C=C3)C(CCN4CCOCC4)=C2C |
Biological Activity
| Description | GW-405833 is a selective agonist of the cannabinoid receptor 2 (CB2), with an EC50 value of 0.65 nM. It exhibits a strong affinity for CB2, while displaying significantly lower activity at CB1, with EC50 and Ki values of 16.1 μM and 4772 nM, respectively. In addition to its agonistic effects at CB2, GW-405833 acts as a non-competitive antagonist at CB1, mediating analgesic and anti-inflammatory effects. Furthermore, it inhibits forskolin-stimulated cAMP production and down-regulates HIF-1α, potentially alleviating acute liver failure through modulation of glycolysis. This compound is useful for research in pain management, inflammation, and liver pathology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
