Product Data Sheet
Kukoamine A
Catalog No. A26307
Kukoamine A is a spermine alkaloid that targets key enzymatic pathways, acting as an inhibitor of trypanothione reductase and lipoxygenase. This compound demonstrates significant biological activities, including the inhibition of cancer cell proliferation and migration, as well as induction of G0/G1 phase cell cycle arrest and apoptosis. Kukoamine A also exerts neuroprotective effects and induces autophagy, making it valuable for research in cancer, inflammation, and metabolic disorders, as well as neurological diseases such as glioblastoma and Parkinson's disease. Its ability to modulate inflammatory responses further highlights its potential as a therapeutic agent in various diseases.
Chemical Information
| Catalog Num | A26307 |
|---|---|
| M. Wt | 530.66 |
| Formula | C28H42N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 75288-96-9 |
| Synonyms | |
| SMILES | O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2 |
Biological Activity
| Description | Kukoamine A is a spermine alkaloid that targets key enzymatic pathways, acting as an inhibitor of trypanothione reductase and lipoxygenase. This compound demonstrates significant biological activities, including the inhibition of cancer cell proliferation and migration, as well as induction of G0/G1 phase cell cycle arrest and apoptosis. Kukoamine A also exerts neuroprotective effects and induces autophagy, making it valuable for research in cancer, inflammation, and metabolic disorders, as well as neurological diseases such as glioblastoma and Parkinson's disease. Its ability to modulate inflammatory responses further highlights its potential as a therapeutic agent in various diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
