Product Data Sheet
ZYJ-34c
Catalog No. A26350
ZYJ-34c is a potent histone deacetylase inhibitor (HDACi) that effectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.056 μM and 0.146 μM, respectively. At low concentrations, ZYJ-34c induces G1 phase cell cycle arrest and demonstrates significant antiproliferative activity. In preclinical studies, it shows substantial antitumor effects in MDA-MB-231 and HCT116 xenograft models and reveals antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model, highlighting its applicability in cancer research.
Chemical Information
| Catalog Num | A26350 |
|---|---|
| M. Wt | 582.69 |
| Formula | C31H42N4O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1314556-93-8 |
| Synonyms | |
| SMILES | CC(C)(C)CC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O |
Biological Activity
| Description | ZYJ-34c is a potent histone deacetylase inhibitor (HDACi) that effectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.056 μM and 0.146 μM, respectively. At low concentrations, ZYJ-34c induces G1 phase cell cycle arrest and demonstrates significant antiproliferative activity. In preclinical studies, it shows substantial antitumor effects in MDA-MB-231 and HCT116 xenograft models and reveals antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model, highlighting its applicability in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
