Product Data Sheet
GK718
Catalog No. A26388
GK718 is a potent inhibitor of histone deacetylases 1 and 3 (HDAC1/3), exhibiting IC50 values of 259 nM and 139 nM, respectively. This compound effectively increases the levels of acetylated histone H3 in cells, indicating its potential for altering epigenetic regulation. Additionally, GK718 has demonstrated efficacy in inhibiting Bleomycin-induced pulmonary fibrosis in murine models, making it relevant for research into fibrotic diseases and epigenetic modifications.
Chemical Information
| Catalog Num | A26388 |
|---|---|
| M. Wt | 517.45 |
| Formula | C26H30Cl2N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032392-65-4 |
| Synonyms | |
| SMILES | O=C([C@@H]1NCCC1)NCC2=CC=C(OCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)C=C2.Cl.Cl |
Biological Activity
| Description | GK718 is a potent inhibitor of histone deacetylases 1 and 3 (HDAC1/3), exhibiting IC50 values of 259 nM and 139 nM, respectively. This compound effectively increases the levels of acetylated histone H3 in cells, indicating its potential for altering epigenetic regulation. Additionally, GK718 has demonstrated efficacy in inhibiting Bleomycin-induced pulmonary fibrosis in murine models, making it relevant for research into fibrotic diseases and epigenetic modifications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
