Product Data Sheet
HDAC8/BRPF1-IN-1
Catalog No. A26391
HDAC8/BRPF1-IN-1 is a dual inhibitor targeting HDAC8 and BRPF1, demonstrating an IC50 of 443 nM for HDAC8 and a Kd of 67 nM for BRPF1 in human cells. This compound exhibits minimal activity against HDAC1 and HDAC6, making it a selective tool for probing histone deacetylation pathways. It is valuable for investigating the roles of HDAC8 and BRPF1 in gene regulation and potential therapeutic strategies in cancer research.
Chemical Information
| Catalog Num | A26391 |
|---|---|
| M. Wt | 417.44 |
| Formula | C19H19N3O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2484255-85-6 |
| Synonyms | |
| SMILES | O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1 |
Biological Activity
| Description | HDAC8/BRPF1-IN-1 is a dual inhibitor targeting HDAC8 and BRPF1, demonstrating an IC50 of 443 nM for HDAC8 and a Kd of 67 nM for BRPF1 in human cells. This compound exhibits minimal activity against HDAC1 and HDAC6, making it a selective tool for probing histone deacetylation pathways. It is valuable for investigating the roles of HDAC8 and BRPF1 in gene regulation and potential therapeutic strategies in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
