Product Data Sheet
HDAC3-IN-8
Catalog No. A26393
HDAC3-IN-8 is a selective inhibitor targeting histone deacetylase 3 (HDAC3) with an IC50 of 0.38 nM, along with notable inhibition of HDAC1 and HDAC2 at 3.52 nM and 15.14 nM, respectively. This compound demonstrates high selectivity for HDAC3 and modulates histone deacetylase activity, making it a valuable tool for epigenetic research. HDAC3-IN-8 is particularly applicable in studies focused on acute myeloid leukemia (AML) and can be utilized in the development of HDAC3-targeted PROTAC degraders.
Chemical Information
| Catalog Num | A26393 |
|---|---|
| M. Wt | 351.40 |
| Formula | C20H21N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2763368-90-5 |
| Synonyms | |
| SMILES | O=C(C1=CC2=CC=CC=C2O1)NCC3=CC=C(C(NNCCC)=O)C=C3 |
Biological Activity
| Description | HDAC3-IN-8 is a selective inhibitor targeting histone deacetylase 3 (HDAC3) with an IC50 of 0.38 nM, along with notable inhibition of HDAC1 and HDAC2 at 3.52 nM and 15.14 nM, respectively. This compound demonstrates high selectivity for HDAC3 and modulates histone deacetylase activity, making it a valuable tool for epigenetic research. HDAC3-IN-8 is particularly applicable in studies focused on acute myeloid leukemia (AML) and can be utilized in the development of HDAC3-targeted PROTAC degraders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
