Product Data Sheet
HPO-DAEE
Catalog No. A26406
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) acts as an inducer of heme oxygenase-1 (HO-1) through the activation of the Nrf2-antioxidant response element (ARE) signaling pathway. This compound promotes the upregulation of various antioxidant genes, providing protective effects against oxidative stress. Additionally, HPO-DAEE exhibits histone deacetylase inhibition, leading to increased expression of extracellular superoxide dismutase via histone acetylation. It has demonstrated efficacy in mitigating cell death induced by 6-hydroxydopamine through the activation of both the Nrf2-ARE and eIF2α-ATF4 pathways, making it a valuable tool for research in oxidative stress-related studies.
Chemical Information
| Catalog Num | A26406 |
|---|---|
| M. Wt | 230.30 |
| Formula | C12H22O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1895934-61-8 |
| Synonyms | 4-Hydroperoxy-2-decenoic acid ethyl ester |
| SMILES | CCCCCCC(OO)/C=C/C(OCC)=O |
Biological Activity
| Description | HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) acts as an inducer of heme oxygenase-1 (HO-1) through the activation of the Nrf2-antioxidant response element (ARE) signaling pathway. This compound promotes the upregulation of various antioxidant genes, providing protective effects against oxidative stress. Additionally, HPO-DAEE exhibits histone deacetylase inhibition, leading to increased expression of extracellular superoxide dismutase via histone acetylation. It has demonstrated efficacy in mitigating cell death induced by 6-hydroxydopamine through the activation of both the Nrf2-ARE and eIF2α-ATF4 pathways, making it a valuable tool for research in oxidative stress-related studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
