Product Data Sheet
H8-A5
Catalog No. A26408
H8-A5 is a specific inhibitor of human histone deacetylase 8 (HDAC8) that employs a zinc-binding group (ZBG) within its pharmacophore design to enhance its selectivity. With IC50 values ranging from 1.8 to 1.9 μM, H8-A5 demonstrates potent antiproliferative activity in MDA-MB-231 breast cancer cells, making it a valuable tool for cancer research. Molecular docking and dynamics studies indicate strong binding affinity to HDAC8, suggesting its potential for therapeutic development in targeting HDAC-mediated pathways in oncology.
Chemical Information
| Catalog Num | A26408 |
|---|---|
| M. Wt | 326.29 |
| Formula | C14H9F3N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 423731-10-6 |
| Synonyms | |
| SMILES | O=C(C(F)(F)F)C1=CC=C(CSC2=NC3=C(N2)C=CC=C3)O1 |
Biological Activity
| Description | H8-A5 is a specific inhibitor of human histone deacetylase 8 (HDAC8) that employs a zinc-binding group (ZBG) within its pharmacophore design to enhance its selectivity. With IC50 values ranging from 1.8 to 1.9 μM, H8-A5 demonstrates potent antiproliferative activity in MDA-MB-231 breast cancer cells, making it a valuable tool for cancer research. Molecular docking and dynamics studies indicate strong binding affinity to HDAC8, suggesting its potential for therapeutic development in targeting HDAC-mediated pathways in oncology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
