Product Data Sheet
G194-0712
Catalog No. A26411
G194-0712 is a selective activator of histone deacetylase 5 (HDAC5), exhibiting an EC50 of 7.96 μM and a Kd of 2.53 μM. This compound promotes ACTN4-K417 deacetylation and enhances nuclear import while upregulating CSTA expression. G194-0712 has demonstrated efficacy in accelerating wound closure in chronic wound models, particularly in reducing wound area and epithelial gaps. Its applications extend to the study of chronic skin wounds, including diabetic, ischemic, and radiation injury-related wounds.
Chemical Information
| Catalog Num | A26411 |
|---|---|
| M. Wt | 353.85 |
| Formula | C20H20ClN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1029737-28-7 |
| Synonyms | |
| SMILES | CC(C1=CC=C(C=C1)N2C=CN=C(C2=O)NCC3=CC=CC=C3Cl)C |
Biological Activity
| Description | G194-0712 is a selective activator of histone deacetylase 5 (HDAC5), exhibiting an EC50 of 7.96 μM and a Kd of 2.53 μM. This compound promotes ACTN4-K417 deacetylation and enhances nuclear import while upregulating CSTA expression. G194-0712 has demonstrated efficacy in accelerating wound closure in chronic wound models, particularly in reducing wound area and epithelial gaps. Its applications extend to the study of chronic skin wounds, including diabetic, ischemic, and radiation injury-related wounds. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
