Product Data Sheet
Tinostamustine hydrochloride
Catalog No. A26428
Tinostamustine hydrochloride is an HDAC inhibitor that exhibits potent anti-multiple myeloma activity. This compound promotes CD38 expression and enhances the acetylation of histone H3, which increases the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab. Additionally, Tinostamustine hydrochloride elevates the expression of MICA and MICB, thereby activating natural killer (NK) cells. Research indicates that this compound can significantly delay tumor growth and improve survival rates in murine models.
Chemical Information
| Catalog Num | A26428 |
|---|---|
| M. Wt | 451.82 |
| Formula | C19H29Cl3N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1793059-58-1 |
| Synonyms | EDO-S101 hydrochloride; NL-101 hydrochloride |
| SMILES | O=C(NO)CCCCCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C.Cl |
Biological Activity
| Description | Tinostamustine hydrochloride is an HDAC inhibitor that exhibits potent anti-multiple myeloma activity. This compound promotes CD38 expression and enhances the acetylation of histone H3, which increases the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab. Additionally, Tinostamustine hydrochloride elevates the expression of MICA and MICB, thereby activating natural killer (NK) cells. Research indicates that this compound can significantly delay tumor growth and improve survival rates in murine models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
