Product Data Sheet
XP5
Catalog No. A26435
XP5 is a potent, orally active inhibitor of HDAC6, exhibiting an IC50 of 31 nM. This compound demonstrates significant antiproliferative activity across various cancer cell lines, including those exhibiting resistance to HDAC inhibitors such as YCC3/7 gastric cancer cells (IC50 = 0.16-2.31 μM). Furthermore, XP5 has been shown to enhance antitumor immunity when used in conjunction with a PD-L1 inhibitor in melanoma research applications.
Chemical Information
| Catalog Num | A26435 |
|---|---|
| M. Wt | 407.48 |
| Formula | C19H25N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2760511-91-7 |
| Synonyms | |
| SMILES | COC1=CC=C(C(OC)=C1)C2=NC=C(S2)C(NCCCCCCC(NO)=O)=O |
Biological Activity
| Description | XP5 is a potent, orally active inhibitor of HDAC6, exhibiting an IC50 of 31 nM. This compound demonstrates significant antiproliferative activity across various cancer cell lines, including those exhibiting resistance to HDAC inhibitors such as YCC3/7 gastric cancer cells (IC50 = 0.16-2.31 μM). Furthermore, XP5 has been shown to enhance antitumor immunity when used in conjunction with a PD-L1 inhibitor in melanoma research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
