Product Data Sheet
HDAC8-IN-12
Catalog No. A26437
HDAC8-IN-12 is a selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 of 0.12 nM. This non-hydroxamic acid compound demonstrates significant anti-tumor activity, particularly in breast cancer models, by activating T cells and skewing the macrophage population towards M1 while reducing M2 macrophages. In an orthotopic mouse model of breast cancer, HDAC8-IN-12 at a dose of 50 mg/kg exhibits notable tumor suppressive effects, making it a valuable tool for research in cancer immunotherapy and epigenetic regulation.
Chemical Information
| Catalog Num | A26437 |
|---|---|
| M. Wt | 331.32 |
| Formula | C16H17N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3028095-13-5 |
| Synonyms | |
| SMILES | CN(/C1=C\C2=CC=C(C(OC)=C2)/C=C/C(NO)=O)C(CNC1=O)=O |
Biological Activity
| Description | HDAC8-IN-12 is a selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 of 0.12 nM. This non-hydroxamic acid compound demonstrates significant anti-tumor activity, particularly in breast cancer models, by activating T cells and skewing the macrophage population towards M1 while reducing M2 macrophages. In an orthotopic mouse model of breast cancer, HDAC8-IN-12 at a dose of 50 mg/kg exhibits notable tumor suppressive effects, making it a valuable tool for research in cancer immunotherapy and epigenetic regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
