Product Data Sheet
Valproic acid-d7 sodium
Catalog No. A26481
Valproic acid-d7 sodium is a deuterium-labeled form of valproic acid sodium salt, an established histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. This compound selectively inhibits HDAC1 (IC50 of 400 μM) and promotes the proteasomal degradation of HDAC2. In addition to its role in modulating HDAC activity, Valproic acid-d7 sodium activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly utilized in research related to epilepsy, bipolar disorder, and migraine prevention.
Chemical Information
| Catalog Num | A26481 |
|---|---|
| M. Wt | 189.24 |
| Formula | C8H8D7NaO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189994-89-5 |
| Synonyms | Sodium Valproate-d7; VPA-d7 sodium; 2-Propylpentanoic acid-d7 sodium |
| SMILES | OCCCC(C(O[Na])=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H] |
Biological Activity
| Description | Valproic acid-d7 sodium is a deuterium-labeled form of valproic acid sodium salt, an established histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. This compound selectively inhibits HDAC1 (IC50 of 400 μM) and promotes the proteasomal degradation of HDAC2. In addition to its role in modulating HDAC activity, Valproic acid-d7 sodium activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly utilized in research related to epilepsy, bipolar disorder, and migraine prevention. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
