Product Data Sheet
HDAC-IN-56
Catalog No. A26489
HDAC-IN-56 is a potent, orally active inhibitor of class I histone deacetylases (HDACs), demonstrating IC50 values of 56.0 ± 6.0 nM for HDAC1, 90.0 ± 5.9 nM for HDAC2, and 422.2 ± 105.1 nM for HDAC3, with minimal activity against HDAC4-11. This compound effectively increases intracellular levels of acetylated histone H3 and P21, leading to G1 cell cycle arrest and apoptosis in tumor cells. HDAC-IN-56 is utilized in cancer research to investigate its therapeutic potential and mechanisms involving HDAC inhibition.
Chemical Information
| Catalog Num | A26489 |
|---|---|
| M. Wt | 485.55 |
| Formula | C28H28FN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2814571-89-4 |
| Synonyms | |
| SMILES | O=C1C=CC(C2=CC=C(C=C2)CN(C)C)=NN1[C@H](C3=CC=C(C=C3)C(NC4=C(N)C=C(C=C4)F)=O)C |
Biological Activity
| Description | HDAC-IN-56 is a potent, orally active inhibitor of class I histone deacetylases (HDACs), demonstrating IC50 values of 56.0 ± 6.0 nM for HDAC1, 90.0 ± 5.9 nM for HDAC2, and 422.2 ± 105.1 nM for HDAC3, with minimal activity against HDAC4-11. This compound effectively increases intracellular levels of acetylated histone H3 and P21, leading to G1 cell cycle arrest and apoptosis in tumor cells. HDAC-IN-56 is utilized in cancer research to investigate its therapeutic potential and mechanisms involving HDAC inhibition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
