Product Data Sheet
ITF5924
Catalog No. A26492
ITF5924 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 7.7 nM. This compound demonstrates over 104-fold selectivity for HDAC6 compared to other HDAC subtypes. The unique difluoromethyl-1,3,4-oxadiazole (DFMO) moiety allows ITF5924 to function as a slow-binding substrate analog, undergoing an enzyme-catalyzed ring-opening reaction that forms a stable and long-lasting enzyme-inhibitor complex. ITF5924 is valuable for studies exploring the role of HDAC6 in various cellular processes and disease states, making it an essential tool for epigenetic research.
Chemical Information
| Catalog Num | A26492 |
|---|---|
| M. Wt | 436.42 |
| Formula | C21H18F2N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2760854-72-4 |
| Synonyms | |
| SMILES | FC(F)C(O1)=NN=C1C(C=C2)=CC=C2CN3N=NC(C4=CC=C(NC5=NCCN5)C=C4)=C3 |
Biological Activity
| Description | ITF5924 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 7.7 nM. This compound demonstrates over 104-fold selectivity for HDAC6 compared to other HDAC subtypes. The unique difluoromethyl-1,3,4-oxadiazole (DFMO) moiety allows ITF5924 to function as a slow-binding substrate analog, undergoing an enzyme-catalyzed ring-opening reaction that forms a stable and long-lasting enzyme-inhibitor complex. ITF5924 is valuable for studies exploring the role of HDAC6 in various cellular processes and disease states, making it an essential tool for epigenetic research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
