Product Data Sheet
4-Iodo-SAHA
Catalog No. A26501
4-Iodo-SAHA is an orally active inhibitor of class I and class II histone deacetylases (HDACs), demonstrating EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM across the Skbr3, HT29, U937, JA16, and HL60 cell lines, respectively. This compound exhibits significant potential for tumor growth inhibition and is valuable for cancer research applications, including the investigation of epigenetic regulation and therapeutic interventions in HDAC-related malignancies.
Chemical Information
| Catalog Num | A26501 |
|---|---|
| M. Wt | 390.22 |
| Formula | C14H19IN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1219807-87-0 |
| Synonyms | ISAHA |
| SMILES | IC1=CC=C(C=C1)NC(CCCCCCC(NO)=O)=O |
Biological Activity
| Description | 4-Iodo-SAHA is an orally active inhibitor of class I and class II histone deacetylases (HDACs), demonstrating EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM across the Skbr3, HT29, U937, JA16, and HL60 cell lines, respectively. This compound exhibits significant potential for tumor growth inhibition and is valuable for cancer research applications, including the investigation of epigenetic regulation and therapeutic interventions in HDAC-related malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
