Product Data Sheet
Valproic acid-d15
Catalog No. A26530
Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts.
Chemical Information
| Catalog Num | A26530 |
|---|---|
| M. Wt | 159.30 |
| Formula | C8HD15O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 362049-65-8 |
| Synonyms | VPA-d15; 2-Propylpentanoic acid-d15 |
| SMILES | [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O)=O)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H] |
Biological Activity
| Description | Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
