Product Data Sheet
Valproic acid-d6
Catalog No. A26539
Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics.
Chemical Information
| Catalog Num | A26539 |
|---|---|
| M. Wt | 150.25 |
| Formula | C8H10D6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 87745-18-4 |
| Synonyms | VPA-d6; 2-Propylpentanoic acid-d6 |
| SMILES | [2H]C([2H])([2H])CCC(C(O)=O)CCC([2H])([2H])[2H] |
Biological Activity
| Description | Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
