Product Data Sheet
PRMT5-IN-28
Catalog No. A26613
PRMT5-IN-28 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5). This compound targets the enzyme responsible for the arginine methylation of various proteins, which plays a crucial role in gene expression regulation, mRNA splicing, and cellular signaling pathways. Inhibition of PRMT5 has been shown to impede cancer cell proliferation and promote apoptosis, making it valuable for research applications in cancer biology and therapeutic development. Additionally, targeting PRMT5 may provide insights into mechanisms of immune evasion in tumors.
Chemical Information
| Catalog Num | A26613 |
|---|---|
| M. Wt | 406.82 |
| Formula | C18H19ClN4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2242753-66-6 |
| Synonyms | |
| SMILES | O[C@H]([C@@H]1O)[C@@H](O[C@]1([H])[C@@H](C(C=C2)=CC=C2Cl)O)N3C(NC=N/C4=N\OC)=C4C=C3 |
Biological Activity
| Description | PRMT5-IN-28 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5). This compound targets the enzyme responsible for the arginine methylation of various proteins, which plays a crucial role in gene expression regulation, mRNA splicing, and cellular signaling pathways. Inhibition of PRMT5 has been shown to impede cancer cell proliferation and promote apoptosis, making it valuable for research applications in cancer biology and therapeutic development. Additionally, targeting PRMT5 may provide insights into mechanisms of immune evasion in tumors. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
