Product Data Sheet
JNJ-7925476
Catalog No. A26620
JNJ-7925476 is a selective inhibitor of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), targeting histone methyltransferase activity. This compound demonstrates rapid absorption, resulting in a brain concentration that is seven times greater than that in plasma. In vivo studies reveal a dose-dependent increase in extracellular levels of serotonin, norepinephrine, and dopamine in the rat cerebral cortex. Additionally, JNJ-7925476 exhibits significant antidepressant-like effects in behavioral assays, highlighting its potential for application in depression research and neuropharmacology.
Chemical Information
| Catalog Num | A26620 |
|---|---|
| M. Wt | 273.37 |
| Formula | C20H19N |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 129540-12-1 |
| Synonyms | |
| SMILES | C#CC1=CC=C(C=C1)[C@@H]2CN3[C@@]([H])(C4=C2C=CC=C4)CCC3 |
Biological Activity
| Description | JNJ-7925476 is a selective inhibitor of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), targeting histone methyltransferase activity. This compound demonstrates rapid absorption, resulting in a brain concentration that is seven times greater than that in plasma. In vivo studies reveal a dose-dependent increase in extracellular levels of serotonin, norepinephrine, and dopamine in the rat cerebral cortex. Additionally, JNJ-7925476 exhibits significant antidepressant-like effects in behavioral assays, highlighting its potential for application in depression research and neuropharmacology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
