Product Data Sheet
CARM1 degrader-2
Catalog No. A26621
CARM1 degrader-2 is a potent PROTAC that specifically targets co-activator associated arginine methyltransferase (CARM1) for degradation, exhibiting a DC50 of 8.8 nM. This compound facilitates the degradation of CARM1 through a VHL- and proteasome-dependent mechanism, leading to the inhibition of methylation of key substrates such as poly(A)-binding protein PABP1 and BAF155. Its ability to inhibit CARM1 function makes CARM1 degrader-2 a valuable tool in breast cancer research, particularly in studies focused on cancer cell migration.
Chemical Information
| Catalog Num | A26621 |
|---|---|
| M. Wt | 1277.71 |
| Formula | C72H100N12O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032785-06-8 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CN2CCN(CC3CCN(CC4CCN(C(CCC5=CC=C(OC6=CC=CC(C(N(C)CC7=CC(C8CCN(CCNC)CC8)=NC=C7)=O)=C6)C=C5)=O)CC4)CC3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C9=CC=C(C%10=C(C)N=CS%10)C=C9)C |
Biological Activity
| Description | CARM1 degrader-2 is a potent PROTAC that specifically targets co-activator associated arginine methyltransferase (CARM1) for degradation, exhibiting a DC50 of 8.8 nM. This compound facilitates the degradation of CARM1 through a VHL- and proteasome-dependent mechanism, leading to the inhibition of methylation of key substrates such as poly(A)-binding protein PABP1 and BAF155. Its ability to inhibit CARM1 function makes CARM1 degrader-2 a valuable tool in breast cancer research, particularly in studies focused on cancer cell migration. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
