Product Data Sheet
(R)-OR-S1
Catalog No. A26630
(R)-OR-S1 is a potent inhibitor of histone methyltransferases EZH1 and EZH2, exhibiting selective dual activity against both enzymes. This reagent has demonstrated the capacity to induce cell differentiation and apoptosis in acute myeloid leukemia (AML) cells, suggesting its potential application in targeted therapy. Notably, (R)-OR-S1 does not lead to significant myelosuppression, allowing for normal hematopoiesis to persist post-treatment, especially when combined with cytarabine. These properties highlight (R)-OR-S1’s promise as a clinically tolerable option for patients undergoing PRC2-targeted treatment in AML.
Chemical Information
| Catalog Num | A26630 |
|---|---|
| M. Wt | 532.47 |
| Formula | C26H34BrN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1809336-19-3 |
| Synonyms | |
| SMILES | O=C(C1=CC(Br)=C(O[C@](C)([C@H]2CC[C@H](N(C)C)CC2)O3)C3=C1C)NCC4=C(C)C=C(C)NC4=O |
Biological Activity
| Description | (R)-OR-S1 is a potent inhibitor of histone methyltransferases EZH1 and EZH2, exhibiting selective dual activity against both enzymes. This reagent has demonstrated the capacity to induce cell differentiation and apoptosis in acute myeloid leukemia (AML) cells, suggesting its potential application in targeted therapy. Notably, (R)-OR-S1 does not lead to significant myelosuppression, allowing for normal hematopoiesis to persist post-treatment, especially when combined with cytarabine. These properties highlight (R)-OR-S1’s promise as a clinically tolerable option for patients undergoing PRC2-targeted treatment in AML. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
