Product Data Sheet
EZH2-IN-5
Catalog No. A26643
EZH2-IN-5 is a highly potent inhibitor of the EZH2 enzyme, exhibiting IC50 values of 1.52 nM for wild-type EZH2 and 4.07 nM for the mutant variant Tyr641. This compound effectively interferes with the methyltransferase activity of EZH2, leading to a reduction in histone methylation. EZH2-IN-5 is utilized in research focused on cancer biology, particularly in hematological malignancies and solid tumors characterized by aberrant EZH2 activity.
Chemical Information
| Catalog Num | A26643 |
|---|---|
| M. Wt | 517.50 |
| Formula | C26H37BrN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1403258-69-4 |
| Synonyms | |
| SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(Br)=C2)C |
Biological Activity
| Description | EZH2-IN-5 is a highly potent inhibitor of the EZH2 enzyme, exhibiting IC50 values of 1.52 nM for wild-type EZH2 and 4.07 nM for the mutant variant Tyr641. This compound effectively interferes with the methyltransferase activity of EZH2, leading to a reduction in histone methylation. EZH2-IN-5 is utilized in research focused on cancer biology, particularly in hematological malignancies and solid tumors characterized by aberrant EZH2 activity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
