Product Data Sheet
ZLD10A
Catalog No. A26646
ZLD10A is a potent and selective inhibitor of the histone methyltransferase EZH2, effectively blocking H3K27 methylation. Demonstrating nanomolar potency against both wild-type and mutant forms of EZH2, ZLD10A exhibits over 1000-fold selectivity compared to other histone methyltransferases. Its ability to inhibit cell proliferation in diffuse large B-cell lymphoma (DLBCL) cell lines in a concentration- and time-dependent manner highlights its potential as an antiproliferative agent. ZLD10A serves as a valuable tool for investigating EZH2 mutant lymphomas.
Chemical Information
| Catalog Num | A26646 |
|---|---|
| M. Wt | 612.80 |
| Formula | C37H48N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1782064-91-8 |
| Synonyms | |
| SMILES | O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(CCCC6)C6=C(C)NC5=O |
Biological Activity
| Description | ZLD10A is a potent and selective inhibitor of the histone methyltransferase EZH2, effectively blocking H3K27 methylation. Demonstrating nanomolar potency against both wild-type and mutant forms of EZH2, ZLD10A exhibits over 1000-fold selectivity compared to other histone methyltransferases. Its ability to inhibit cell proliferation in diffuse large B-cell lymphoma (DLBCL) cell lines in a concentration- and time-dependent manner highlights its potential as an antiproliferative agent. ZLD10A serves as a valuable tool for investigating EZH2 mutant lymphomas. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
