Product Data Sheet
JMV 236
Catalog No. A26649
JMV 236 is a potent histone methyltransferase inhibitor that modulates epigenetic regulation. It exhibits significant appetite-suppressing activity by antagonizing cholecystokinin, influencing the interaction between the intestinal peptide PrRP and the CCK1 receptor. This compound activates PrRP neurons in the nucleus of the solitary tract (NTS), enhancing its effects on food intake regulation, particularly in starvation conditions. JMV 236 is valuable in research applications focused on appetite control and metabolic disorders.
Chemical Information
| Catalog Num | A26649 |
|---|---|
| M. Wt | 1207.31 |
| Formula | C56H74N10O18S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113137-57-8 |
| Synonyms | |
| SMILES | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
Biological Activity
| Description | JMV 236 is a potent histone methyltransferase inhibitor that modulates epigenetic regulation. It exhibits significant appetite-suppressing activity by antagonizing cholecystokinin, influencing the interaction between the intestinal peptide PrRP and the CCK1 receptor. This compound activates PrRP neurons in the nucleus of the solitary tract (NTS), enhancing its effects on food intake regulation, particularly in starvation conditions. JMV 236 is valuable in research applications focused on appetite control and metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
