Product Data Sheet
PRMT1-IN-3
Catalog No. A26662
PRMT1-IN-3 is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), demonstrating an IC50 of 4.11 μM. In addition to its primary activity against PRMT1, it also inhibits PRMT6 and PRMT8 with IC50 values of 23.3 and 30.1 μM, respectively. PRMT1-IN-3 effectively reduces asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells, leading to cell cycle arrest, apoptosis, and decreased migration and colony formation in MDA-MB-231 cells. This compound serves as a potential chemotherapeutic sensitizer for Paclitaxel and is valuable for research concerning TNBC.
Chemical Information
| Catalog Num | A26662 |
|---|---|
| M. Wt | 302.39 |
| Formula | C18H23FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 892570-48-8 |
| Synonyms | |
| SMILES | FC1=CC=C(COC2=C(C=CC=C2)CNCCCNC)C=C1 |
Biological Activity
| Description | PRMT1-IN-3 is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), demonstrating an IC50 of 4.11 μM. In addition to its primary activity against PRMT1, it also inhibits PRMT6 and PRMT8 with IC50 values of 23.3 and 30.1 μM, respectively. PRMT1-IN-3 effectively reduces asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells, leading to cell cycle arrest, apoptosis, and decreased migration and colony formation in MDA-MB-231 cells. This compound serves as a potential chemotherapeutic sensitizer for Paclitaxel and is valuable for research concerning TNBC. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
