Product Data Sheet
EZH2-IN-23
Catalog No. A26670
EZH2-IN-23 is a selective inhibitor of the EZH2 enzyme, exhibiting potent inhibition of the PRC2 complex with an IC50 of 0.8 nM. It effectively reduces H3K27 trimethylation in cellular assays with an IC50 of 40 nM, making it a valuable tool for studying epigenetic regulation. Additionally, EZH2-IN-23 demonstrates favorable pharmacokinetic properties in rat models, featuring 100% oral bioavailability, which enhances its potential for in vivo research applications.
Chemical Information
| Catalog Num | A26670 |
|---|---|
| M. Wt | 539.13 |
| Formula | C29H35ClN4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3095068-20-2 |
| Synonyms | |
| SMILES | CC(N1)=CC(C)=C(CN2CCC(SC([C@H](C)C3CCN(CC4=NC=C(Cl)C=C4)CC3)=C5C)=C5C2=O)C1=O |
Biological Activity
| Description | EZH2-IN-23 is a selective inhibitor of the EZH2 enzyme, exhibiting potent inhibition of the PRC2 complex with an IC50 of 0.8 nM. It effectively reduces H3K27 trimethylation in cellular assays with an IC50 of 40 nM, making it a valuable tool for studying epigenetic regulation. Additionally, EZH2-IN-23 demonstrates favorable pharmacokinetic properties in rat models, featuring 100% oral bioavailability, which enhances its potential for in vivo research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
