Product Data Sheet
PRMT5-MTA-IN-3-d3
Catalog No. A26693
PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer.
Chemical Information
| Catalog Num | A26693 |
|---|---|
| M. Wt | 437.39 |
| Formula | C19H14D3F3N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3052146-54-7 |
| Synonyms | |
| SMILES | CN1N=CC2=C1C(N)=NC=C2NC(C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C([2H])([2H])[2H])=O)=O |
Biological Activity
| Description | PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
