Product Data Sheet
EZH2-IN-1
Catalog No. A26700
EZH2-IN-1 is a selective inhibitor targeting EZH2 and EZH1 through a SAM-competitive mechanism. It demonstrates potent inhibition with IC50 values of 32 nM for wild-type EZH2, 197 nM for the EZH2 Y641N mutant, and 213 nM for EZH1. This compound effectively reduces levels of bulk H3K27me3 and H3K27me2, highlighting its potential utility in research related to diffuse large B cell lymphoma.
Chemical Information
| Catalog Num | A26700 |
|---|---|
| M. Wt | 490.00 |
| Formula | C27H28ClN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1377997-28-8 |
| Synonyms | |
| SMILES | O=C(NC1CC(C)(C)NC(C)(C)C1)C2=CC=C(OC3=CC=CC(C4=CC=NN=C4)=C3C#N)C(Cl)=C2 |
Biological Activity
| Description | EZH2-IN-1 is a selective inhibitor targeting EZH2 and EZH1 through a SAM-competitive mechanism. It demonstrates potent inhibition with IC50 values of 32 nM for wild-type EZH2, 197 nM for the EZH2 Y641N mutant, and 213 nM for EZH1. This compound effectively reduces levels of bulk H3K27me3 and H3K27me2, highlighting its potential utility in research related to diffuse large B cell lymphoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
