Product Data Sheet
Furamidine
Catalog No. A26702
Furamidine is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), exhibiting an IC50 of 9.4 μM, while maintaining a considerably lower affinity for PRMT5, PRMT6, and PRMT4. Additionally, Furamidine acts as a reversible, competitive inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP-1), demonstrating enhanced inhibition with duplex DNA substrates. This compound has applications in research focusing on methylation patterns and DNA repair mechanisms, as well as serving as an antiparasitic agent.
Chemical Information
| Catalog Num | A26702 |
|---|---|
| M. Wt | 304.35 |
| Formula | C18H16N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 73819-26-8 |
| Synonyms | DB75; NSC 305831 |
| SMILES | N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(N)=N)C=C3)O2)C=C1)N |
Biological Activity
| Description | Furamidine is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), exhibiting an IC50 of 9.4 μM, while maintaining a considerably lower affinity for PRMT5, PRMT6, and PRMT4. Additionally, Furamidine acts as a reversible, competitive inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP-1), demonstrating enhanced inhibition with duplex DNA substrates. This compound has applications in research focusing on methylation patterns and DNA repair mechanisms, as well as serving as an antiparasitic agent. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
