Product Data Sheet
EZH2-IN-16
Catalog No. A26703
EZH2-IN-16 is a potent inhibitor of the histone methyltransferase EZH2, targeting both the wild-type and the Y641F mutant forms with IC50 values of 37.6 nM and 79.1 nM, respectively. This compound effectively inhibits the proliferation of WSU-DLCL2 cells, demonstrating a GI50 of 0.2 μM. EZH2-IN-16 is valuable for research applications focused on epigenetic regulation and oncology, particularly in the context of EZH2-related pathways in cancer progression.
Chemical Information
| Catalog Num | A26703 |
|---|---|
| M. Wt | 542.67 |
| Formula | C32H38N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2238820-26-1 |
| Synonyms | |
| SMILES | O=C(C1=CC(C2=CC=C(N3CCOCC3)C=C2)=CC(N(CC)C(C4CC4)=O)=C1C)NCC5=C(C)C=C(C)NC5=O |
Biological Activity
| Description | EZH2-IN-16 is a potent inhibitor of the histone methyltransferase EZH2, targeting both the wild-type and the Y641F mutant forms with IC50 values of 37.6 nM and 79.1 nM, respectively. This compound effectively inhibits the proliferation of WSU-DLCL2 cells, demonstrating a GI50 of 0.2 μM. EZH2-IN-16 is valuable for research applications focused on epigenetic regulation and oncology, particularly in the context of EZH2-related pathways in cancer progression. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
