Product Data Sheet
DCG066
Catalog No. A26715
DCG066 is a selective inhibitor of the lysine methyltransferase G9a, effectively binding to G9a and obstructing its methyltransferase activity in vitro. This compound has been shown to decrease di-methylation levels of histone H3 at lysine 9 (H3K9Me2), leading to inhibition of cell proliferation and induction of apoptosis. Additionally, DCG066 exhibits low cytotoxicity in leukemia cell lines characterized by elevated G9a expression, such as K562, making it a valuable tool for studying the role of G9a in oncogenesis and potential therapeutic applications.
Chemical Information
| Catalog Num | A26715 |
|---|---|
| M. Wt | 579.58 |
| Formula | C30H31F6N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 494786-13-9 |
| Synonyms | |
| SMILES | O=C(N(C)C)NC1=CC=C(C=C1)CN2CCC(CC2)C(O)(C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F |
Biological Activity
| Description | DCG066 is a selective inhibitor of the lysine methyltransferase G9a, effectively binding to G9a and obstructing its methyltransferase activity in vitro. This compound has been shown to decrease di-methylation levels of histone H3 at lysine 9 (H3K9Me2), leading to inhibition of cell proliferation and induction of apoptosis. Additionally, DCG066 exhibits low cytotoxicity in leukemia cell lines characterized by elevated G9a expression, such as K562, making it a valuable tool for studying the role of G9a in oncogenesis and potential therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
