Product Data Sheet
(R)-HH2853
Catalog No. A26719
(R)-HH2853 is a selective inhibitor of the EZH2 enzyme, specifically targeting the mutant EZH2-Y641F variant with an IC50 of less than 100 nM. This compound demonstrates potential in therapeutic applications related to cancer and autoimmune diseases, enabling researchers to investigate its effects on histone methylation and gene regulation. Its specificity for mutant EZH2 may provide insights into mechanisms of malignancy and contribute to the development of novel treatment strategies.
Chemical Information
| Catalog Num | A26719 |
|---|---|
| M. Wt | 611.66 |
| Formula | C31H36F3N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2202678-06-4 |
| Synonyms | |
| SMILES | C[C@@H](N1CCN(CC1)CC(F)(F)F)C2=C(C)C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=CC4=C(C5=CC=C(N=N5)C)C=CN24 |
Biological Activity
| Description | (R)-HH2853 is a selective inhibitor of the EZH2 enzyme, specifically targeting the mutant EZH2-Y641F variant with an IC50 of less than 100 nM. This compound demonstrates potential in therapeutic applications related to cancer and autoimmune diseases, enabling researchers to investigate its effects on histone methylation and gene regulation. Its specificity for mutant EZH2 may provide insights into mechanisms of malignancy and contribute to the development of novel treatment strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
