Product Data Sheet
PRT543
Catalog No. A26722
PRT543 is a selective inhibitor of the histone methyltransferase PRMT5, targeting key epigenetic modifications associated with various cancers and hematological disorders. This compound demonstrates significant efficacy in inhibiting PRMT5 activity, leading to alterations in gene expression and cellular phenotypes relevant to cancer progression and disorders such as sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH). PRT543 serves as a valuable tool for researchers investigating the role of PRMT5 in epigenetic regulation and its potential as a therapeutic target.
Chemical Information
| Catalog Num | A26722 |
|---|---|
| M. Wt | 425.27 |
| Formula | C18H18Cl2N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2278356-90-2 |
| Synonyms | |
| SMILES | O[C@@]1(C)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3C=C2)O[C@@H]1[C@H](O)C4=CC=C(Cl)C(Cl)=C4 |
Biological Activity
| Description | PRT543 is a selective inhibitor of the histone methyltransferase PRMT5, targeting key epigenetic modifications associated with various cancers and hematological disorders. This compound demonstrates significant efficacy in inhibiting PRMT5 activity, leading to alterations in gene expression and cellular phenotypes relevant to cancer progression and disorders such as sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH). PRT543 serves as a valuable tool for researchers investigating the role of PRMT5 in epigenetic regulation and its potential as a therapeutic target. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
