Product Data Sheet
SKLB-0124
Catalog No. A26724
SKLB-0124 is a selective degrader of Protein Arginine Methyltransferase 6 (PRMT6) with an IC50 of 1.6 μM. This compound induces proteasome-dependent degradation of PRMT6, resulting in significant inhibition of cell proliferation and the induction of apoptosis and cell cycle arrest. SKLB-0124 has demonstrated DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells, making it a valuable reagent for researching lung and breast cancer. It does not degrade PRMT1 or PRMT8, ensuring specificity in studies involving PRMT6.
Chemical Information
| Catalog Num | A26724 |
|---|---|
| M. Wt | 531.73 |
| Formula | C32H45N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3065966-31-3 |
| Synonyms | |
| SMILES | O=C(NCCCC(NC1=CC=C(C2=CN=CC(CN(C)CCNC)=C2)C=C1)=O)CC34C[C@H](C[C@@H]5C4)C[C@H](C5)C3 |
Biological Activity
| Description | SKLB-0124 is a selective degrader of Protein Arginine Methyltransferase 6 (PRMT6) with an IC50 of 1.6 μM. This compound induces proteasome-dependent degradation of PRMT6, resulting in significant inhibition of cell proliferation and the induction of apoptosis and cell cycle arrest. SKLB-0124 has demonstrated DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells, making it a valuable reagent for researching lung and breast cancer. It does not degrade PRMT1 or PRMT8, ensuring specificity in studies involving PRMT6. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
