Product Data Sheet
GSK3368715 trihydrochloride
Catalog No. A26725
GSK3368715 trihydrochloride is a highly selective inhibitor targeting type I protein arginine methyltransferases (PRMTs), demonstrating a remarkable capacity to inhibit PRMT1 (IC50 = 3.1 nM) and other isoforms such as PRMT6 and PRMT8. As an uncompetitive inhibitor of S-adenosyl-L-methionine, this compound significantly affects arginine methylation patterns and alters exon usage. GSK3368715 trihydrochloride has shown promising anti-cancer activity, making it a valuable tool for research into the role of PRMTs in disease mechanisms and therapeutic development.
Chemical Information
| Catalog Num | A26725 |
|---|---|
| M. Wt | 475.92 |
| Formula | C20H41Cl3N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2227587-26-8 |
| Synonyms | EPZ019997 trihydrochloride |
| SMILES | CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C.Cl.Cl.Cl |
Biological Activity
| Description | GSK3368715 trihydrochloride is a highly selective inhibitor targeting type I protein arginine methyltransferases (PRMTs), demonstrating a remarkable capacity to inhibit PRMT1 (IC50 = 3.1 nM) and other isoforms such as PRMT6 and PRMT8. As an uncompetitive inhibitor of S-adenosyl-L-methionine, this compound significantly affects arginine methylation patterns and alters exon usage. GSK3368715 trihydrochloride has shown promising anti-cancer activity, making it a valuable tool for research into the role of PRMTs in disease mechanisms and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
