Product Data Sheet
Dot1L-IN-6
Catalog No. A26727
Dot1L-IN-6 is a potent inhibitor of the DOT1L enzyme, demonstrating an IC50 value of 0.19 nM. This compound effectively disrupts the function of the telomeric silencing 1-like protein, making it a valuable tool for exploring the role of DOT1L in various biological processes. Researchers can utilize Dot1L-IN-6 in studies related to epigenetics, gene regulation, and the development of therapies for diseases associated with abnormal DOT1L activity.
Chemical Information
| Catalog Num | A26727 |
|---|---|
| M. Wt | 606.99 |
| Formula | C25H21ClF2N6O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2565705-01-1 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(N[C@H](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(OC)=NC(OC)=N5)=C1)(C)=O |
Biological Activity
| Description | Dot1L-IN-6 is a potent inhibitor of the DOT1L enzyme, demonstrating an IC50 value of 0.19 nM. This compound effectively disrupts the function of the telomeric silencing 1-like protein, making it a valuable tool for exploring the role of DOT1L in various biological processes. Researchers can utilize Dot1L-IN-6 in studies related to epigenetics, gene regulation, and the development of therapies for diseases associated with abnormal DOT1L activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
