Product Data Sheet
PRMT5-IN-48
Catalog No. A26736
PRMT5-IN-48 is a potent inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibiting an IC50 of 20.7 nM. This compound effectively inhibits the growth of various cancer cell lines while inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is valuable for research focused on non-Hodgkin lymphoma and other malignancies associated with PRMT5 dysregulation.
Chemical Information
| Catalog Num | A26736 |
|---|---|
| M. Wt | 515.65 |
| Formula | C30H37N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2640287-77-8 |
| Synonyms | |
| SMILES | O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5 |
Biological Activity
| Description | PRMT5-IN-48 is a potent inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibiting an IC50 of 20.7 nM. This compound effectively inhibits the growth of various cancer cell lines while inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is valuable for research focused on non-Hodgkin lymphoma and other malignancies associated with PRMT5 dysregulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
