Product Data Sheet
IHMT-EZH2-426
Catalog No. A26737
IHMT-EZH2-426 is a potent covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for wild-type EZH2 and 1.2 nM and 1.7-3.5 nM against the mutants EZH2-A687V and EZH2-Y641F/Y641N/Y641S, respectively. This compound effectively reduces levels of H3K27me3 and EZH2, exhibiting significant anti-proliferative activity in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines. It is a valuable tool for research aimed at understanding EZH2's role in oncogenesis and potential therapeutic interventions.
Chemical Information
| Catalog Num | A26737 |
|---|---|
| M. Wt | 578.70 |
| Formula | C31H35FN4O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3018914-66-1 |
| Synonyms | |
| SMILES | O=C(C1=CC(C(C=CC(F)=C2)=C2NC(C=C)=O)=CC(N(C3CCOCC3)C)=C1C)NCC4=C(SC)C=C(C)NC4=O |
Biological Activity
| Description | IHMT-EZH2-426 is a potent covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for wild-type EZH2 and 1.2 nM and 1.7-3.5 nM against the mutants EZH2-A687V and EZH2-Y641F/Y641N/Y641S, respectively. This compound effectively reduces levels of H3K27me3 and EZH2, exhibiting significant anti-proliferative activity in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines. It is a valuable tool for research aimed at understanding EZH2's role in oncogenesis and potential therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
