Product Data Sheet
PRMT5-MTA-IN-1
Catalog No. A26740
PRMT5-MTA-IN-1 is a selective inhibitor of protein arginine methyltransferase PRMT5, targeting its enzymatic activity. This compound effectively inhibits the proliferation of colorectal cancer cells, including HCT116 wildtype and MTAP del mutant strains, with an IC50 of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 shows favorable liver microsomal stability and membrane permeability, indicating potential for in vivo applications. Its promising pharmacokinetic profile was observed in CD-1 mice, supporting further research into its therapeutic efficacy.
Chemical Information
| Catalog Num | A26740 |
|---|---|
| M. Wt | 449.40 |
| Formula | C22H19F4N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3048425-88-0 |
| Synonyms | |
| SMILES | CC1=C(C(N)=NC2=CC(F)=C(C=C21)C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)CO |
Biological Activity
| Description | PRMT5-MTA-IN-1 is a selective inhibitor of protein arginine methyltransferase PRMT5, targeting its enzymatic activity. This compound effectively inhibits the proliferation of colorectal cancer cells, including HCT116 wildtype and MTAP del mutant strains, with an IC50 of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 shows favorable liver microsomal stability and membrane permeability, indicating potential for in vivo applications. Its promising pharmacokinetic profile was observed in CD-1 mice, supporting further research into its therapeutic efficacy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
