Product Data Sheet
Bisegliptin
Catalog No. A26741
Bisegliptin is a small molecule inhibitor targeting histone methyltransferases, primarily recognized for its antidiabetic properties. It undergoes metabolic conversion, predominantly transforming the cyano group into a carboxylic acid form, with DPP-4 contributing to its metabolism. The resultant carboxylic acid metabolite can be detected in both in vivo and in vitro settings. Research indicates that co-administration with other DPP inhibitors influences the plasma concentration of this metabolite, highlighting the complexity of its metabolic dynamics. Additionally, the amide intermediate demonstrates a significantly faster conversion rate than the parent compound in the presence of DPP-4, underscoring its relevance in metabolic studies.
Chemical Information
| Catalog Num | A26741 |
|---|---|
| M. Wt | 351.42 |
| Formula | C18H26FN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 862501-61-9 |
| Synonyms | KRP-104 |
| SMILES | CCOC(C12CCC(CC2)(NCC(N3C[C@@H](F)C[C@H]3C#N)=O)CC1)=O |
Biological Activity
| Description | Bisegliptin is a small molecule inhibitor targeting histone methyltransferases, primarily recognized for its antidiabetic properties. It undergoes metabolic conversion, predominantly transforming the cyano group into a carboxylic acid form, with DPP-4 contributing to its metabolism. The resultant carboxylic acid metabolite can be detected in both in vivo and in vitro settings. Research indicates that co-administration with other DPP inhibitors influences the plasma concentration of this metabolite, highlighting the complexity of its metabolic dynamics. Additionally, the amide intermediate demonstrates a significantly faster conversion rate than the parent compound in the presence of DPP-4, underscoring its relevance in metabolic studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
