Product Data Sheet
CARM1-IN-1
Catalog No. A26750
CARM1-IN-1 is a potent and selective inhibitor of the histone methyltransferase CARM1, with an IC50 value of 8.6 μM and minimal activity against PRMT1 and SET7 (IC50 >667 μM). This compound effectively reduces the methylation activity of CARM1 on various substrates, including PABP1, CA150, SmB, and histone H3. Additionally, CARM1-IN-1 has been shown to suppress the promoter activity of prostate-specific antigen (PSA) while displaying low cytotoxicity, making it a valuable tool for studying epigenetic regulation and prostate cancer biology.
Chemical Information
| Catalog Num | A26750 |
|---|---|
| M. Wt | 555.26 |
| Formula | C26H21Br2NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1020399-49-8 |
| Synonyms | |
| SMILES | O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4 |
Biological Activity
| Description | CARM1-IN-1 is a potent and selective inhibitor of the histone methyltransferase CARM1, with an IC50 value of 8.6 μM and minimal activity against PRMT1 and SET7 (IC50 >667 μM). This compound effectively reduces the methylation activity of CARM1 on various substrates, including PABP1, CA150, SmB, and histone H3. Additionally, CARM1-IN-1 has been shown to suppress the promoter activity of prostate-specific antigen (PSA) while displaying low cytotoxicity, making it a valuable tool for studying epigenetic regulation and prostate cancer biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
