Product Data Sheet
ZLD1039
Catalog No. A26753
ZLD1039 is a highly selective and orally bioavailable inhibitor of the EZH2 enzyme, targeting its role in the polycomb repressive complex 2 (PRC2). This compound demonstrates potent inhibition of PRC2 enzymatic activity against both wild-type and mutant EZH2 variants, with IC50 values of 5.6 nM for wild-type, 15 nM for Y641F, and 4.0 nM for A677G. ZLD1039 has been shown to inhibit breast tumor growth and metastasis, making it a valuable tool for research in cancer biology and therapeutic exploration.
Chemical Information
| Catalog Num | A26753 |
|---|---|
| M. Wt | 612.80 |
| Formula | C36H48N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1826865-46-6 |
| Synonyms | |
| SMILES | O=C(NCC1=C2CCCCC2=C(C)NC1=O)C3=CC(C4=CC=C(N5CCN(C)CC5)N=C4)=CC(N(CC)C6CCOCC6)=C3C |
Biological Activity
| Description | ZLD1039 is a highly selective and orally bioavailable inhibitor of the EZH2 enzyme, targeting its role in the polycomb repressive complex 2 (PRC2). This compound demonstrates potent inhibition of PRC2 enzymatic activity against both wild-type and mutant EZH2 variants, with IC50 values of 5.6 nM for wild-type, 15 nM for Y641F, and 4.0 nM for A677G. ZLD1039 has been shown to inhibit breast tumor growth and metastasis, making it a valuable tool for research in cancer biology and therapeutic exploration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
