Product Data Sheet
LEM-14
Catalog No. A26754
LEM-14 is a selective inhibitor of NSD2, demonstrating an IC50 of 132 µM. It shows minimal activity against NSD1 and lacks activity towards NSD3. This compound effectively inhibits fibrotic gene expression in non-diabetic bone marrow-derived macrophages (BMDMs) and, when used in combination with ionizing radiation, enhances apoptosis rates and reduces colony formation in colorectal cancer cells. Additionally, LEM-14 has been shown to improve anti-tumor efficacy in Balb/c nude mice with LoVo cell xenografts, making it a promising candidate for research into multiple myeloma and colorectal cancer.
Chemical Information
| Catalog Num | A26754 |
|---|---|
| M. Wt | 478.56 |
| Formula | C25H26N4O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1814881-70-3 |
| Synonyms | |
| SMILES | O=C1C(C2=C(CCCC2)S3)=C3NC(CN4CCN(C([C@H]5CC6=CC=CC=C6C(O5)=O)=O)CC4)=N1 |
Biological Activity
| Description | LEM-14 is a selective inhibitor of NSD2, demonstrating an IC50 of 132 µM. It shows minimal activity against NSD1 and lacks activity towards NSD3. This compound effectively inhibits fibrotic gene expression in non-diabetic bone marrow-derived macrophages (BMDMs) and, when used in combination with ionizing radiation, enhances apoptosis rates and reduces colony formation in colorectal cancer cells. Additionally, LEM-14 has been shown to improve anti-tumor efficacy in Balb/c nude mice with LoVo cell xenografts, making it a promising candidate for research into multiple myeloma and colorectal cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
