Product Data Sheet
OTS193320
Catalog No. A26762
OTS193320 is an imidazo[1,2-a]pyridine compound that acts as a selective inhibitor of the SUV39H2 methyltransferase. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, leading to apoptosis. Additionally, the combination of OTS193320 with Doxorubicin has been shown to significantly decrease γ-H2AX levels and enhance the reduction in cancer cell viability compared to the use of either compound alone. This makes OTS193320 a valuable tool for understanding the role of histone modifications in cancer therapy.
Chemical Information
| Catalog Num | A26762 |
|---|---|
| M. Wt | 536.02 |
| Formula | C28H30ClN5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2093401-33-1 |
| Synonyms | |
| SMILES | O=[N+](C1=CC=C(CN[C@@H]2CC[C@H](NC3=CC4=NC(C5=CC(Cl)=C(OC)C=C5OC)=CN4C=C3)CC2)C=C1)[O-] |
Biological Activity
| Description | OTS193320 is an imidazo[1,2-a]pyridine compound that acts as a selective inhibitor of the SUV39H2 methyltransferase. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, leading to apoptosis. Additionally, the combination of OTS193320 with Doxorubicin has been shown to significantly decrease γ-H2AX levels and enhance the reduction in cancer cell viability compared to the use of either compound alone. This makes OTS193320 a valuable tool for understanding the role of histone modifications in cancer therapy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
