Product Data Sheet
BIX-01294 trihydrochloride
Catalog No. A26768
BIX-01294 trihydrochloride is a reversible and selective inhibitor of G9a and GLP histone methyltransferases, with reported IC50 values of 1.7 μM and 0.9 μM, respectively. It functions by competing for binding at the N-terminal site of substrate lysine residues, thereby inhibiting methylation processes. BIX-01294 trihydrochloride has been shown to induce necroptosis and autophagy, demonstrating antitumor activity particularly in recurrent tumor cells. Its utilization in research may further elucidate the roles of histone methylation in cancer biology and potential therapeutic strategies.
Chemical Information
| Catalog Num | A26768 |
|---|---|
| M. Wt | 600.02 |
| Formula | C28H41Cl3N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1392399-03-9 |
| Synonyms | |
| SMILES | CN(CCC1)CCN1C2=NC(C=C(OC)C(OC)=C3)=C3C(NC4CCN(CC5=CC=CC=C5)CC4)=N2.Cl.Cl.Cl |
Biological Activity
| Description | BIX-01294 trihydrochloride is a reversible and selective inhibitor of G9a and GLP histone methyltransferases, with reported IC50 values of 1.7 μM and 0.9 μM, respectively. It functions by competing for binding at the N-terminal site of substrate lysine residues, thereby inhibiting methylation processes. BIX-01294 trihydrochloride has been shown to induce necroptosis and autophagy, demonstrating antitumor activity particularly in recurrent tumor cells. Its utilization in research may further elucidate the roles of histone methylation in cancer biology and potential therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
