Product Data Sheet
MS8511
Catalog No. A26782
MS8511 is a selective, irreversible inhibitor of G9a and GLP that covalently targets a cysteine residue within the substrate binding site. It demonstrates IC50 values of 100 nM for G9a and 140 nM for GLP, with Kd values of 44 nM and 46 nM, respectively. MS8511 effectively decreases cellular levels of H3K9me2 and enhances antiproliferative activity, making it a valuable tool for researching various cancers, including brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as conditions such as Alzheimer’s disease, sickle cell disease, and Prader−Willi syndrome.
Chemical Information
| Catalog Num | A26782 |
|---|---|
| M. Wt | 495.66 |
| Formula | C28H41N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2866408-21-9 |
| Synonyms | |
| SMILES | COC1=CC(C(C=C1OCCCN2CCCC2)=NC(NC(C=C)=O)=C3)=C3NC4CCN(CC4)C(C)C |
Biological Activity
| Description | MS8511 is a selective, irreversible inhibitor of G9a and GLP that covalently targets a cysteine residue within the substrate binding site. It demonstrates IC50 values of 100 nM for G9a and 140 nM for GLP, with Kd values of 44 nM and 46 nM, respectively. MS8511 effectively decreases cellular levels of H3K9me2 and enhances antiproliferative activity, making it a valuable tool for researching various cancers, including brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as conditions such as Alzheimer’s disease, sickle cell disease, and Prader−Willi syndrome. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
