Product Data Sheet
PRMT7-IN-2
Catalog No. A26799
PRMT7-IN-2 is a selective inhibitor of Protein Arginine Methyltransferase 7 (PRMT7) with an IC50 value of 0.50 μM. This compound effectively arrests the cell cycle at the G0/G1 phase and promotes apoptosis, leading to inhibition of cell growth both in vivo and in vitro. PRMT7-IN-2 decreases monomethylarginine levels associated with PRMT7 activity and modulates epithelial and mesenchymal marker expression, enhancing the levels of E-cadherin while reducing those of N-cadherin, Vimentin, and ZEB2. Such properties make it a valuable tool for studying cancer biology and cellular transformation mechanisms.
Chemical Information
| Catalog Num | A26799 |
|---|---|
| M. Wt | 473.55 |
| Formula | C25H23N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3058094-83-7 |
| Synonyms | |
| SMILES | COC1=CC(C2=NC3=C(C(NC4=CC=C(C5=C4)N=C(C=C5N)C)=N2)SC=C3)=CC(OC)=C1OC |
Biological Activity
| Description | PRMT7-IN-2 is a selective inhibitor of Protein Arginine Methyltransferase 7 (PRMT7) with an IC50 value of 0.50 μM. This compound effectively arrests the cell cycle at the G0/G1 phase and promotes apoptosis, leading to inhibition of cell growth both in vivo and in vitro. PRMT7-IN-2 decreases monomethylarginine levels associated with PRMT7 activity and modulates epithelial and mesenchymal marker expression, enhancing the levels of E-cadherin while reducing those of N-cadherin, Vimentin, and ZEB2. Such properties make it a valuable tool for studying cancer biology and cellular transformation mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
