Product Data Sheet
(S)-HH2853
Catalog No. A26808
(S)-HH2853 is a potent dual inhibitor of EZH1 and EZH2, specifically targeting the EZH2_Y641F variant with an IC50 of less than 100 nM. This pyridine-based compound demonstrates significant biological activity, making it a valuable tool for research in anti-tumor and autoimmune disease pathways. Its ability to modulate histone methylation presents opportunities for exploring epigenetic regulation in various therapeutic contexts.
Chemical Information
| Catalog Num | A26808 |
|---|---|
| M. Wt | 611.66 |
| Formula | C31H36F3N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2202678-05-3 |
| Synonyms | |
| SMILES | C[C@H](N1CCN(CC1)CC(F)(F)F)C2=C(C)C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=CC4=C(C5=CC=C(N=N5)C)C=CN24 |
Biological Activity
| Description | (S)-HH2853 is a potent dual inhibitor of EZH1 and EZH2, specifically targeting the EZH2_Y641F variant with an IC50 of less than 100 nM. This pyridine-based compound demonstrates significant biological activity, making it a valuable tool for research in anti-tumor and autoimmune disease pathways. Its ability to modulate histone methylation presents opportunities for exploring epigenetic regulation in various therapeutic contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
